Addison's Disease
About the disease & condition
Aetiology & Pathophysiology
- Primary cause:** Autoimmune adrenalitis (most common in developed countries), where the immune system attacks adrenal cortex cells.

Common symptoms:** Fatigue, weight loss, anorexia, nausea, abdominal pain, salt craving, and hyperpigmentation (especially in sun-exposed areas, skin folds, and mucous membranes).
Red-flag/severe symptoms:**
Clinical assessment:** History and physical exam focusing on fatigue, hyperpigmentation, hypotension, and electrolyte abnormalities.
Laboratory tests:**
Imaging:** Abdominal CT to assess adrenal gland structure (e.g., atrophy, calcifications, masses).
Pharmacological:**
Non-pharmacological:**
Adrenal crisis:** Life-threatening hypotension, shock, and death if untreated.
Chronic complications: Electrolyte imbalances, hypoglycemia, and increased susceptibility to infections.
Reduced quality of life due to persistent fatigue and need for lifelong medication.
Prevention:** No known preventive measures for autoimmune cases; early treatment of infections (e.g., TB) may reduce risk.
Follow-up:**
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